Article
The role of genetics and epigenetics in the pathogenesis of systemic sclerosis.
Nature reviews. Rheumatology - 1 Nov 2014
Broen Jasper C A, Radstake Timothy R D J, Rossato Marzia
Abstract excerpt
Systemic sclerosis (SSc) is a complex autoimmune disease of unclear aetiology. A multitude of genetic studies, ranging from candidate-gene studies to genome-wide association studies, have identified a large number of genetic susceptibility factors for SSc and its clinical phenotypes, but the contribution of these factors to disease susceptibility is only modest. However, in an endeavour to explore how the...
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