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Article

Epigenetics, the holy grail in the pathogenesis of systemic sclerosis

16 Apr 2014

Abstract excerpt

The objective of this review is to present evidence that supports the central role of epigenetic regulation in the pathogenesis of SSc. SSc is a complex autoimmune disease characterized by immune activation, fibrosis of the skin and internal organs and obliterative vasculopathy affecting predominantly the microvessels. Remarkable progress has been made in the past few years emphasizing the importance of...

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PMID: 24740406
DOI: 10.1093/rheumatology/keu155

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