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Article

Genetic variation in inflammatory and bone turnover pathways and risk of osteolytic responses to prosthetic materials.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society - 1 Feb 2015

MacInnes Scott J, Del Vescovo Elena, Kiss-Toth Endre, Ollier William E R, Kay Peter R, Gordon Andrew, Greenfield Edward M, Wilkinson Mark J

Abstract excerpt

Wear particle-induced inflammatory bone loss (osteolysis) is the leading cause of total hip arthroplasty (THA) failure. Individual susceptibility to osteolysis is modulated by genetic variation. In this 2-stage case-control association study we examined whether variation within candidate genes in inflammatory and bone turnover signaling pathways associates with susceptibility to osteolysis and time to prosthesis...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25399506
DOI: 10.1002/jor.22755

Genes

TIRAP
KREMEN2
SFRP1
LRP5
LRP6
NOD2
SOST
SQSTM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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