Article
Do genetic susceptibility, Toll-like receptors, and pathogen-associated molecular patterns modulate the effects of wear?
Clinical orthopaedics and related research - 1 Dec 2014
Greenfield Edward M
Abstract excerpt
BACKGROUND: Overwhelming evidence supports the concept that wear particles are the primary initiator of aseptic loosening of orthopaedic implants. It is likely, however, that other factors modulate the biologic response to wear particles. This review focuses on three potential other factors: genetic susceptibility, Toll-like receptors (TLRs), and bacterial pathogen-associated molecular patterns (PAMPs). WHERE ARE...
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