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Article

Genetic susceptibility to hip arthroplasty failure--association with the RANK/OPG pathway.

International orthopaedics - 1 Jun 2006

Malik M H A, Bayat A, Jury F, Ollier W E R, Kay P R

Abstract excerpt

The OPG/RANK/RANKL system has been implicated in the biological cascade of events initiated by particulate wear debris and bacterial infection resulting in periprosthetic bone loss around total hip arthroplasties (THA). Individual responses to such stimuli may be dictated by genetic variation caused by single nucleotide polymorphisms (SNPs). Case control study of the osteoprotegerin and RANK genes for possible...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16583245
DOI: 10.1007/s00264-006-0074-2
PMCID: PMC2532089

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