Mechanisms of disease: genetics of Paget's disease of bone and related disorders.

Abstract excerpt

Paget's disease of bone (PDB) is a common disorder in which focal abnormalities of increased bone turnover lead to complications such as bone pain, deformity, pathological fractures, and deafness. PDB has a strong genetic component and several susceptibility loci for the disease have been identified by genome-wide scans. Mutations that predispose individuals to PDB and related disorders have been identified in...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Myositis, Inclusion Body
• Share to Osteitis Deformans
• Share to Osteolysis