Article
Genome-wide association identifies three new susceptibility loci for Paget's disease of bone.
Nature genetics - 29 May 2011
Albagha Omar M E, Wani Sachin E, Visconti Micaela R, Alonso Nerea, Goodman Kirsteen, Brandi Maria Luisa, Cundy Tim, Chung Pui Yan Jenny, Dargie Rosemary, Devogelaer Jean-Pierre, Falchetti Alberto, Fraser William D, Gennari Luigi, Gianfrancesco Fernando, Hooper Michael J, Van Hul Wim, Isaia Gianluca, Nicholson Geoff C, Nuti Ranuccio, Papapoulos Socrates, Montes Javier del Pino, Ratajczak Thomas, Rea Sarah L, Rendina Domenico, Gonzalez-Sarmiento Rogelio, Di Stefano Marco, Ward Lynley C, Walsh John P, Ralston Stuart H
Abstract excerpt
Paget's disease of bone (PDB) is a common disorder characterized by focal abnormalities of bone remodeling. We previously identified variants at the CSF1, OPTN and TNFRSF11A loci as risk factors for PDB by genome-wide association study. Here we extended this study, identified three new loci and confirmed their association with PDB in 2,215 affected individuals (cases) and 4,370 controls from seven independent...
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