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Article

Genetic susceptibility to aseptic loosening following total hip and knee arthroplasty: a systematic review of candidate-gene and genome-wide association studies.

British medical bulletin - 3 Jul 2026

Maffulli Nicola, Spiezia Filippo, Del Buono Angelo, Oliva Francesco

Abstract excerpt

INTRODUCTION: Aseptic loosening is the leading cause of revision after total hip (THA) and knee (TKA) arthroplasty, accounting for 33%-50% of revisions. Variable individual susceptibility suggests genetic contributions. SOURCES OF DATA: Five databases searched to 9 June 2026. Studies reporting genetic associations with aseptic loosening or osteolysis in THA/TKA were included. Quality was assessed via Q-Genie....

Topics

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Arthroplasty, Replacement, Hip
Arthroplasty, Replacement, Knee
Genetic Predisposition to Disease
Genome-Wide Association Study
Osteolysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

Tumor Necrosis Factor-alpha

Source

Identifiers

PMID: 42574754
DOI: 10.1093/bmb/ldag025

Genes

IL1RN
TNF
BCL2
CALCA
KREMEN2
SFRP1
TIRAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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