Article
Allelic variation, aneuploidy, and nongenetic mechanisms suppress a monogenic trait in yeast.
Genetics - 1 Jan 2015
Sirr Amy, Cromie Gareth A, Jeffery Eric W, Gilbert Teresa L, Ludlow Catherine L, Scott Adrian C, Dudley Aimée M
Abstract excerpt
Clinically relevant features of monogenic diseases, including severity of symptoms and age of onset, can vary widely in response to environmental differences as well as to the presence of genetic modifiers affecting the trait's penetrance and expressivity. While a better understanding of modifier loci could lead to treatments for Mendelian diseases, the rarity of individuals harboring both a disease-causing...
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