Contemporary, yeast-based approaches to understanding human genetic variation.

Abstract excerpt

Determining how genetic variation contributes to human health and disease is a critical challenge. As one of the most genetically tractable model organisms, yeast has played a central role in meeting this challenge. The advent of new technologies, including high-throughput DNA sequencing and synthesis, proteomics, and computational methods, has vastly increased the power of yeast-based approaches to determine the...

Topics

• Genetic Complementation Test
• Genetic Predisposition to Disease
• Genetic Variation
• Genome-Wide Association Study
• High-Throughput Nucleotide Sequencing
• Humans
• Models, Genetic
• Proteomics
• Saccharomyces cerevisiae