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High-Throughput Sequencing Analyses of XX Genital Ridges Lacking FOXL2 Reveal DMRT1 Up-Regulation Before SOX9 Expression During the Sex-Reversal Process in Goats1

14 Nov 2014

Abstract excerpt

FOXL2 loss of function in goats leads to the early transdifferentiation of ovaries into testes, then to the full sex reversal of XX homozygous mutants. By contrast, Foxl2 loss of function in mice induces an arrest of follicle formation after birth, followed by complete female sterility. In order to understand the molecular role of FOXL2 during ovarian differentiation in the goat species, putative FOXL2 target...

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PMID: 25395674
DOI: 10.1095/biolreprod.114.122796

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