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Article

Expression studies of the PIS-regulated genes suggest different mechanisms of sex determination within mammals.

Cytogenetic and genome research - 1 Jan 2003

Pannetier M, Servel N, Cocquet J, Besnard N, Cotinot C, Pailhoux E

Abstract excerpt

In mammals, the Y-located SRY gene is known to induce testis formation from the indifferent gonad. A related gene, SOX9, also plays a critical role in testis differentiation in mammals, in birds and reptiles. It is now assumed that SRY acts upstream of SOX9 in the sex determination cascade, but the regulatory link which should exist between these two genes remains unknown. Studies on XX sex reversal in polled...

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Source

Identifiers

PMID: 14684983
DOI: 10.1159/000074337

Genes

SOX9
FOXL2
SRY

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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