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Article

Genome-wide identification of FOXL2 binding and characterization of FOXL2 feminizing action in the fetal gonads

5 Sept 2018

Abstract excerpt

The identity of the gonads is determined by which fate, ovarian granulosa cell or testicular Sertoli cell, the bipotential somatic cell precursors choose to follow. In most vertebrates, the conserved transcription factor FOXL2 contributes to the fate of granulosa cells. To understand FOXL2 functions during gonad differentiation, we performed genome-wide analysis of FOXL2 chromatin occupancy in fetal ovaries and...

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PMID: 30212841
DOI: 10.1093/hmg/ddy312

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