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Article

Viral infection. Prevention and cure of rotavirus infection via TLR5/NLRC4-mediated production of IL-22 and IL-18.

Science (New York, N.Y.) - 14 Nov 2014

Zhang Benyue, Chassaing Benoit, Shi Zhenda, Uchiyama Robin, Zhang Zhan, Denning Timothy L, Crawford Sue E, Pruijssers Andrea J, Iskarpatyoti Jason A, Estes Mary K, Dermody Terence S, Ouyang Wenjun, Williams Ifor R, Vijay-Kumar Matam, Gewirtz Andrew T

Abstract excerpt

Activators of innate immunity may have the potential to combat a broad range of infectious agents. We report that treatment with bacterial flagellin prevented rotavirus (RV) infection in mice and cured chronically RV-infected mice. Protection was independent of adaptive immunity and interferon (IFN, type I and II) and required flagellin receptors Toll-like receptor 5 (TLR5) and NOD-like receptor C4 (NLRC4)....

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Source

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Identifiers

PMID: 25395539
DOI: 10.1126/science.1256999
PMCID: PMC4788408

Genes

NLRC4
TLR5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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