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Article

Recognition of Double-Stranded RNA by TLR3 Induces Severe Small Intestinal Injury in Mice

1 Apr 2007

Abstract excerpt

The role of TLRs on intestinal epithelial cells (IECs) is controversial, and the mechanisms by which TLRs influence mucosal homeostasis are obscure. In this study, we report that genomic dsRNA from rotavirus, and its synthetic analog polyinosinic-polycytidylic acid (poly(I:C)), induce severe mucosal injury in the small intestine. Upon engaging TLR3 on IECs, dsRNA triggers IECs to secrete IL-15, which functions to...

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PMID: 17372013
DOI: 10.4049/jimmunol.178.7.4548

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