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Article

Type III and Not Type I Interferons Efficiently Prevent the Spread of Rotavirus in Human Intestinal Epithelial Cells.

Journal of virology - 14 Sept 2022

Doldan Patricio, Dai Jin, Metz-Zumaran Camila, Patton John T, Stanifer Megan L, Boulant Steeve

Abstract excerpt

Rotavirus infects intestinal epithelial cells and is the leading cause of gastroenteritis in infants worldwide. Upon viral infection, intestinal cells produce type I and type III interferons (IFNs) to alert the tissue and promote an antiviral state. These two types of IFN bind to different receptors but induce similar pathways that stimulate the activation of interferon-stimulated genes (ISGs) to combat viral...

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Identifiers

PMID: 36000839
DOI: 10.1128/jvi.00706-22
PMCID: PMC9472630

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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