Article
IL-22 suppresses the infection of porcine enteric coronaviruses and rotavirus by activating STAT3 signal pathway.
Antiviral research - 1 Jun 2017
Xue Mei, Zhao Jing, Ying Lan, Fu Fang, Li Lin, Ma Yanlong, Shi Hongyan, Zhang Jiaoer, Feng Li, Liu Pinghuang
Abstract excerpt
Interleukin-22 (IL-22), a member of the IL-10 superfamily, plays essential roles in fighting against mucosal microbial infection and maintaining mucosal barrier integrity within the intestine. However, little knowledge exists on the ability of porcine IL-22 (pIL-22) to fight against viral infection in the gut. In this study, we found that recombinant mature pIL-22 (mpIL-22) inhibited the infection of multiple...
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