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Article

A genomic and evolutionary approach reveals non-genetic drug resistance in malaria.

Genome biology - 1 Jan 2014

Herman Jonathan D, Rice Daniel P, Ribacke Ulf, Silterra Jacob, Deik Amy A, Moss Eli L, Broadbent Kate M, Neafsey Daniel E, Desai Michael M, Clish Clary B, Mazitschek Ralph, Wirth Dyann F

Abstract excerpt

BACKGROUND: Drug resistance remains a major public health challenge for malaria treatment and eradication. Individual loci associated with drug resistance to many antimalarials have been identified, but their epistasis with other resistance mechanisms has not yet been elucidated. RESULTS: We previously described two mutations in the cytoplasmic prolyl-tRNA synthetase (cPRS) gene that confer resistance to...

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Identifiers

PMID: 25395010
DOI: 10.1186/PREACCEPT-1067113631444973
PMCID: PMC4272547

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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