Article
Experimental evolution, genetic analysis and genome re-sequencing reveal the mutation conferring artemisinin resistance in an isogenic lineage of malaria parasites.
BMC genomics - 16 Sept 2010
Hunt Paul, Martinelli Axel, Modrzynska Katarzyna, Borges Sofia, Creasey Alison, Rodrigues Louise, Beraldi Dario, Loewe Laurence, Fawcett Richard, Kumar Sujai, Thomson Marian, Trivedi Urmi, Otto Thomas D, Pain Arnab, Blaxter Mark, Cravo Pedro
Abstract excerpt
BACKGROUND: Classical and quantitative linkage analyses of genetic crosses have traditionally been used to map genes of interest, such as those conferring chloroquine or quinine resistance in malaria parasites. Next-generation sequencing technologies now present the possibility of determining genome-wide genetic variation at single base-pair resolution. Here, we combine in vivo experimental evolution, a rapid...
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