Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ResMAP-a saturation mutagenesis platform enabling parallel profiling of target-specific resistance-conferring mutations in Plasmodium.

mBio - 16 Oct 2024

Wall Richard J, MacGowan Stuart A, Hallyburton Irene, Syed Aisha J, Ajay Castro Sowmya, Dey Gourav, Milne Rachel, Patterson Stephen, Phelan Jody, Wiedemar Natalie, Wyllie Susan

Abstract excerpt

New and improved drugs are required for the treatment and ultimate eradication of malaria. The efficacy of front-line therapies is now threatened by emerging drug resistance; thus, new tools to support the development of drugs with a lower propensity for resistance are needed. Here, we describe the development of a RESistance Mapping And Profiling (ResMAP) platform for the identification of resistance-conferring...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antimalarials
Share to Drug Resistance

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutagenesis

Share to Mutation

Share to Plasmodium falciparum

Source

Open in PubMed Open full text

Identifiers

PMID: 39191404
DOI: 10.1128/mbio.01708-24
PMCID: PMC11481570

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ResMAP-a saturation mutagenesis platform enabling parallel profiling of target-specific resistance-conferring mutations in Plasmodium.PMID 39191404Read ↗

Predicting Drug Resistance Using Deep Mutational Scanning.Semantic proximity Read ↗

Systematic in vitro evolution in Plasmodium falciparum reveals key determinants of drug resistanceSemantic proximity Read ↗

Understanding drug resistance in malaria parasites: Basic science for public healthSemantic proximity Read ↗

Generation of a mutator parasite to drive resistome discovery in Plasmodium falciparum.Semantic proximity Read ↗

Structural analyses of the malaria parasite aminoacyl‐tRNA synthetases provide new avenues for antimalarial drug discoverySemantic proximity Read ↗

Mechanistic insights into dual-active liver and blood-stage antiplasmodials.Semantic proximity Read ↗

Mapping the malaria parasite druggable genome by using in vitro evolution and chemogenomics.Semantic proximity Read ↗

Genomic analysis of single nucleotide polymorphisms in malaria parasite drug targets.Semantic proximity Read ↗

Quantitative genome re-sequencing defines multiple mutations conferring chloroquine resistance in rodent malaria.Semantic proximity Read ↗

Quinoxaline-Based Anti-Schistosomal Compounds Have Potent Anti-Malarial ActivitySemantic proximity Read ↗

Quinoxaline-based anti-schistosomal compounds have potent anti-plasmodial activitySemantic proximity Read ↗

Pyrimethamine-sulfadoxine resistance in Plasmodium falciparum: what next?Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.