Article
Function-based mutation-resistant synthetic signaling device activated by HIV-1 proteolysis.
ACS synthetic biology - 19 Jun 2015
Majerle Andreja, Gaber Rok, Benčina Mojca, Jerala Roman
Abstract excerpt
The high mutation rate of the human immunodeficiency virus type 1 (HIV-1) virus is a major problem since it evades the function of antibodies and chemical inhibitors. Here, we demonstrate a viral detection strategy based on synthetic biology principles to detect a specific viral function rather than a particular viral protein. The resistance caused by mutations can be circumvented since the mutations that cause...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.