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Immunomimetic Designer Cells Protect Mice from MRSA Infection

21 Jun 2018

Abstract excerpt

Many community- and hospital-acquired bacterial infections are caused by antibiotic-resistant pathogens. Methicillin-resistant Staphylococcus aureus (MRSA) predisposes humans to invasive infections that are difficult to eradicate. We designed a closed-loop gene network programming mammalian cells to autonomously detect and eliminate bacterial infections. The genetic circuit contains human Toll-like receptors as...

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PMID: 29937224
DOI: 10.1016/j.cell.2018.05.039

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