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Article

Artificial signaling in mammalian cells enabled by prokaryotic two-component system.

Nature chemical biology - 1 Feb 2020

Mazé Alain, Benenson Yaakov

Abstract excerpt

Augmenting live cells with new signal transduction capabilities is a key objective in genetic engineering and synthetic biology. We showed earlier that two-component signaling pathways could function in mammalian cells, albeit while losing their ligand sensitivity. Here, we show how to transduce small-molecule ligands in a dose-dependent fashion into gene expression in mammalian cells using two-component...

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Identifiers

PMID: 31844302
DOI: 10.1038/s41589-019-0429-9
PMCID: PMC6982536

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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