Article
Chemical-induced cancer incidence and underlying mechanisms in Fen1 mutant mice.
Oncogene - 3 Mar 2011
Xu H, Zheng L, Dai H, Zhou M, Hua Y, Shen B
Abstract excerpt
A critical observation in sporadic cancers is that not all individuals are equally prone to developing cancer following exposure to a given environmental carcinogen. Epidemiological studies have suggested that the difference in the timing of cancer onset in response to exogenous DNA damage is likely attributable to genetic variations, such as those associated with base excision repair (BER) genes. To test this...
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