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Article

Robust homology-directed repair within mouse mammary tissue is not specifically affected by Brca2 mutation.

Nature communications - 25 Oct 2016

Kass Elizabeth M, Lim Pei Xin, Helgadottir Hildur R, Moynahan Mary Ellen, Jasin Maria

Abstract excerpt

The mammary gland undergoes significant proliferative stages after birth, but little is known about how the developmental changes impact DNA double-strand break (DSB) repair. Mutations in multiple genes involved in homology-directed repair (HDR), considered a particularly accurate pathway for repairing DSBs, are linked to breast cancer susceptibility, including BRCA2. Using reporter mice that express an inducible...

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Share to BRCA2 Protein
Share to DNA Breaks, Double-Stranded

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mammary Glands, Animal

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Source

Open in PubMed Open full text

Identifiers

PMID: 27779185
DOI: 10.1038/ncomms13241
PMCID: PMC5093336

Genes

BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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