Article
Nucleotide excision repair and B lymphoma: somatic hypermutation is not the only culprit.
Cell cycle (Georgetown, Tex.) - 15 Jul 2011
Hyka-Nouspikel Nevila, Nouspikel Thierry
Abstract excerpt
Different mechanisms account for the development of B lymphoma. Malignant transformation of B lymphocytes arises from progressive loss of genome integrity combined with uncontrolled cell proliferation, often triggered by foreign or self antigens. It is well established that somatic hypermutation, the pathway responsible for introducing high levels of mutations in immunoglobulin genes, also targets several other...
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