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Article

The BMP pathway either enhances or inhibits the Wnt pathway depending on the SMAD4 and p53 status in CRC

13 Nov 2014

Abstract excerpt

BACKGROUND: Constitutive Wnt activation is essential for colorectal cancer (CRC) initiation but also underlies the cancer stem cell phenotype, metastasis and chemosensitivity. Importantly Wnt activity is still modulated as evidenced by higher Wnt activity at the invasive front of clonal tumours termed the β-catenin paradox. SMAD4 and p53 mutation status and the bone morphogenetic protein (BMP) pathway are known...

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PMID: 25393365
DOI: 10.1038/bjc.2014.560

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