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Article

Bone morphogenetic protein 4 induces differentiation of colorectal cancer stem cells and increases their response to chemotherapy in mice.

Gastroenterology - 1 Jan 2011

Lombardo Ylenia, Scopelliti Alessandro, Cammareri Patrizia, Todaro Matilde, Iovino Flora, Ricci-Vitiani Lucia, Gulotta Gaspare, Dieli Francesco, de Maria Ruggero, Stassi Giorgio

Abstract excerpt

BACKGROUND & AIMS: The limited clinical response observed in many patients with colorectal cancer may be related to the presence of chemoresistant colorectal cancer stem cells (CRC-SCs). Bone morphogenetic protein 4 (BMP4) promotes the differentiation of normal colonic stem cells. We investigated whether BMP4 might be used to induce differentiation of CRC-SCs and for therapeutic purposes. METHODS: CRC-SCs were...

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Identifiers

PMID: 20951698
DOI: 10.1053/j.gastro.2010.10.005

Genes

BMP4
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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