Article

Reciprocal epigenetic Sox2 regulation by SMAD1-SMAD3 is critical for anoikis resistance and metastasis in cancer

2022-01-12

Abstract excerpt

<h4>Summary</h4> Growth factors in the tumor environment are key regulators of cell survival and metastasis. Here we reveal, dichotomy between TGF-β superfamily growth factors BMP and TGF-β/activin, and their downstream SMAD effectors. Gene expression profiling uncovered Sox2 as a key signaling node regulated in an opposing manner by anoikis-promoting BMP2, 4 and 9, and anoikis-suppressing TGF-β and activin A. We...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5d1482a3-1cd6-5380-994f-94383b4180e6
DOI: 10.1101/2022.01.11.475900

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Reciprocal epigenetic Sox2 regulation by SMAD1-SMAD3 is critical for anoikis resistance and metastasis in cancerDOI 10.1101/2022.01.11.475900Read

SOX4 can redirect TGF-β-mediated SMAD3-transcriptional output in a context-dependent manner to promote tumorigenesisSemantic proximity Read

Transforming growth factor-β employs HMGA2 to elicit epithelial–mesenchymal transitionSemantic proximity Read

SMAD Proteins in TGF-β Signalling Pathway in Cancer: Regulatory Mechanisms and Clinical ApplicationsSemantic proximity Read

Novel bone morphogenetic protein signaling through Smad2 and Smad3 to regulate cancer progression and developmentSemantic proximity Read

p53 and ΔNp63α Coregulate the Transcriptional and Cellular Response to TGFβ and BMP SignalsSemantic proximity Read

A SNAIL1–SMAD3/4 transcriptional repressor complex promotes TGF-β mediated epithelial–mesenchymal transitionSemantic proximity Read

SOX2 Targets Fibronectin 1 to Promote Cell Migration and Invasion in Ovarian Cancer: New Molecular Leads for Therapeutic InterventionSemantic proximity Read

Clinical Correlation of Transcription Factor SOX3 in Cancer: Unveiling Its Role in TumorigenesisSemantic proximity Read

SMAD3 Activation: A Converging Point of Dysregulated TGF-Beta Superfamily Signaling and Genetic Aberrations in Granulosa Cell Tumor Development?Semantic proximity Read

Transcriptional cofactors Ski and SnoN are major regulators of the TGF-β/Smad signaling pathway in health and diseaseSemantic proximity Read

TGF-β and the Smad Signaling Pathway Support Transcriptomic Reprogramming during Epithelial-Mesenchymal Cell TransitionSemantic proximity Read

The Smads.Semantic proximity Read