Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

SMAD4 mutations do not preclude epithelial-mesenchymal transition in colorectal cancer.

Oncogene - 1 Feb 2022

Frey Patrick, Devisme Antoine, Rose Katja, Schrempp Monika, Freihen Vivien, Andrieux Geoffroy, Boerries Melanie, Hecht Andreas

Abstract excerpt

Transforming growth factor beta (TGFβ) superfamily signaling is a prime inducer of epithelial-mesenchymal transitions (EMT) that foster cancer cell invasion and metastasis, a major cause of cancer-related deaths. Yet, TGFβ signaling is frequently inactivated in human tumor entities including colorectal cancer (CRC) and pancreatic adenocarcinoma (PAAD) with a high proportion of mutations incapacitating SMAD4,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Line, Tumor
Share to Colorectal Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epithelial-Mesenchymal Transition

Share to Gene Expression Regulation, Neoplastic

Share to Signal Transduction

Share to Smad4 Protein

Share to Snail Family Transcription Factors

Share to Transforming Growth Factor beta

Source

Open in PubMed Open full text

Identifiers

PMID: 34857888
DOI: 10.1038/s41388-021-02128-2
PMCID: PMC8816731

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

SMAD4 mutations do not preclude epithelial-mesenchymal transition in colorectal cancer.PMID 34857888Read ↗

Canonical BMP Signaling Executes Epithelial-Mesenchymal Transition Downstream of SNAIL1Semantic proximity Read ↗

TGFβ-induced SMAD4-dependent Apoptosis Proceeded by EMT in CRCSemantic proximity Read ↗

SMAD2, SMAD3 and SMAD4 mutations in colorectal cancer.Semantic proximity Read ↗

The role of TGF-β/SMAD4 signaling in cancer.Semantic proximity Read ↗

Loss of p53 epigenetically modulates epithelial to mesenchymal transition in colorectal cancerSemantic proximity Read ↗

Colorectal Cancer-Associated Smad4 R361 Hotspot Mutations Boost Wnt/β-Catenin Signaling through Enhanced Smad4-LEF1 Binding.Semantic proximity Read ↗

Epithelial-mesenchymal Transition and Its Role in the Pathogenesis of Colorectal CancerSemantic proximity Read ↗

TGFβ1-Induced EMT in the MCF10A Mammary Epithelial Cell Line Model Is Executed Independently of SNAIL1 and ZEB1 but Relies on JUNB-Coordinated Transcriptional RegulationSemantic proximity Read ↗

Smad4 Dependency Defines Two Classes of Transforming Growth Factor β (TGF-β) Target Genes and Distinguishes TGF-β-Induced Epithelial-Mesenchymal Transition from Its Antiproliferative and Migratory ResponsesSemantic proximity Read ↗

Prognostic role and clinicopathological features of SMAD4 gene mutation in colorectal cancer: a systematic review and meta-analysis.Semantic proximity Read ↗

Prognostic role and clinicopathological features of SMAD4 gene mutation in colorectal cancer: a systematic review and meta-analysisSemantic proximity Read ↗

Smad4 and epithelial–mesenchymal transition proteins in colorectal carcinoma: an immunohistochemical studySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.