Article
Basophils control T-cell responses and limit disease activity in experimental murine colitis.
Mucosal immunology - 1 Jan 2014
Gomez M Rodriguez, Talke Y, Hofmann C, Ketelsen I, Hermann F, Reich B, Goebel N, Schmidbauer K, Dunger N, Brühl H, Renner K, Syed S-N, Mack M
Abstract excerpt
Basophils have been recognized as important inducers of T helper type 2 (Th2) responses. Using the colitis model of adoptive transfer of CD4(+) CD62L(+) T cells into lymphopenic hosts, we have analyzed how basophils regulate T-cell responses and modulate disease activity. Transferred T cells rapi...
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