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Article

NMDA receptor-mediated PIP5K activation to produce PI(4,5)P₂ is essential for AMPA receptor endocytosis during LTD.

Neuron - 12 Jan 2012

Unoki Takamitsu, Matsuda Shinji, Kakegawa Wataru, Van Ngo Thai Bich, Kohda Kazuhisa, Suzuki Atsushi, Funakoshi Yuji, Hasegawa Hiroshi, Yuzaki Michisuke, Kanaho Yasunori

Abstract excerpt

NMDA receptor activation leads to clathrin-dependent endocytosis of postsynaptic AMPA receptors. Although this process controls long-term depression (LTD) induction in the hippocampus, how it is regulated by neuronal activities is not completely clear. Here, we show that Ca²⁺ influx through the N...

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Identifiers

PMID: 22243752
DOI: 10.1016/j.neuron.2011.09.034

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22243752-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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