Article
Oxidative DNA damage is instrumental in hyperreplication stress-induced inviability of Escherichia coli.
Nucleic acids research - 1 Dec 2014
Charbon Godefroid, Bjørn Louise, Mendoza-Chamizo Belén, Frimodt-Møller Jakob, Løbner-Olesen Anders
Abstract excerpt
In Escherichia coli, an increase in the ATP bound form of the DnaA initiator protein results in hyperinitiation and inviability. Here, we show that such replication stress is tolerated during anaerobic growth. In hyperinitiating cells, a shift from anaerobic to aerobic growth resulted in appearance of fragmented chromosomes and a decrease in terminus concentration, leading to a dramatic increase in ori/ter ratio...
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