The use of integrating DNA vectors to analyse the molecular defects in ionising radiation-sensitive mutants of mammalian cells including ataxia telangiectasia.

doi:10.1016/0165-1110(89)90024-9

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Article

The use of integrating DNA vectors to analyse the molecular defects in ionising radiation-sensitive mutants of mammalian cells including ataxia telangiectasia.

Mutation research - 1 Jan 2000

Thacker J

Abstract excerpt

Integrating DNA vectors, encoding selectable recombinant genes, were used to assess rejoining and recombination in wild-type mammalian cells and their ionising radiation-sensitive mutants. To provide a simple model of an important radiation-induced lesion - the DNA double-strand break - the vecto...

Topics

Ataxia Telangiectasia
Cell Line
DNA Repair
DNA Restriction Enzymes
Genetic Vectors
Humans
Mutation
Radiation, Ionizing
Recombination, Genetic
Simian virus 40
Transformation, Genetic

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