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Article

Analysis of gene targeting and intrachromosomal homologous recombination stimulated by genomic double-strand breaks in mouse embryonic stem cells.

Molecular and cellular biology - 1 Jul 1998

Donoho G, Jasin M, Berg P

Abstract excerpt

To investigate the effects of in vivo genomic DNA double-strand breaks on the efficiency and mechanisms of gene targeting in mouse embryonic stem cells, we have used a series of insertion and replacement vectors carrying two, one, or no genomic sites for the rare-cutting endonuclease I-SceI. Thes...

Topics

Amino Acid Sequence
Animals
Cell Line
Chromosomes
DNA Damage
Gene Conversion
Gene Targeting
Genotype
Hypoxanthine Phosphoribosyltransferase
Mice
Molecular Sequence Data
Nucleic Acid Heteroduplexes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Recombination, Genetic

Stem Cells

Source

Open in PubMed Open full text

Identifiers

PMID: 9632791
DOI: 10.1128/MCB.18.7.4070
PMCID: PMC108991

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9632791-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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