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Article

Analysis of gene targeting and intrachromosomal homologous recombination stimulated by genomic double-strand breaks in mouse embryonic stem cells.

Molecular and cellular biology - 1 Jul 1998

Donoho G, Jasin M, Berg P

Abstract excerpt

To investigate the effects of in vivo genomic DNA double-strand breaks on the efficiency and mechanisms of gene targeting in mouse embryonic stem cells, we have used a series of insertion and replacement vectors carrying two, one, or no genomic sites for the rare-cutting endonuclease I-SceI. These vectors were introduced into the hypoxanthine phosphoribosyltransferase (hprt) gene to produce substrates for...

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Identifiers

PMID: 9632791
DOI: 10.1128/MCB.18.7.4070
PMCID: PMC108991

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Source receipt: pubmed, retrieved 7 Sept 2026.

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