DNA-break repair, radioresistance of DNA synthesis, and camptothecin sensitivity in the radiation-sensitive irs mutants: comparisons to ataxia-telangiectasia cells.

doi:10.1016/0921-8777(90)90057-c

Back to search

Article

DNA-break repair, radioresistance of DNA synthesis, and camptothecin sensitivity in the radiation-sensitive irs mutants: comparisons to ataxia-telangiectasia cells.

Mutation research - 1 Mar 1990

Thacker J, Ganesh A N

Abstract excerpt

Induction and rejoining of DNA single-strand breaks (ssb) and double-strand breaks (dsb) after gamma-irradiation were measured, respectively, by alkaline and neutral sucrose gradient sedimentation methods. The radiosensitive mutants irs1, irs2, and irs3 showed no significant difference from wild-...

Topics

Animals
Ataxia Telangiectasia
Camptothecin
Cell Line
Cell Line, Transformed
Cricetinae
Cricetulus
DNA
DNA Repair
DNA Replication
Humans
Mutation
Radiation Tolerance

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.