Article
The genetic basis of resistance to ionising radiation damage in cultured mammalian cells.
Mutation research - 1 Mar 1991
Thacker J, Wilkinson R E
Abstract excerpt
To test the genetic similarity of independently-isolated hamster cell mutants sensitive to ionising radiation, these were fused in pairs and the hybrids exposed to X-rays. Some mutants (irs1, irs3, xrs-1, XR-1, BLM2) were found to complement all others tested for radiosensitivity in hybrids, and are therefore in separate genetic groups. The mutants irs2 and V-E5, both isolated from V79 cells, did not complement...
Topics
- Animals
- Cells, Cultured
- Cricetinae
- DNA
- Dose-Response Relationship, Radiation
- Genetic Complementation Test
- Genetic Markers
- Hybrid Cells
- In Vitro Techniques
- Mice
- Mutation
- Radiation Tolerance