Article
The type and yield of ionising radiation induced chromosomal aberrations depend on the efficiency of different DSB repair pathways in mammalian cells.
Mutation research - 3 Jul 2008
Natarajan Adayapalam T, Berni Andrea, Marimuthu Kodumudi M, Palitti Fabrizio
Abstract excerpt
In order to evaluate the relative role of two major DNA double strand break repair pathways, i.e., non-homologous end joining (NHEJ) and homologous recombination repair (HRR), CHO mutants deficient in these two pathways and the parental cells (AA8) were X-irradiated with various doses. The cells were harvested at different times after irradiation, representing G2, S and G1 phase at the time of irradiation, The...
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