Mutagenic and chromosomal events in radiation transformation.

Abstract excerpt

The transformation of a normal cell to a cancer cell is a complex multi-stage process. Data are presented from rodent cells which suggest that the initial radiation induced change does not represent a mutation in a specific structural gene or group of genes. Rather, DNA damage induced by radiation produces a heritable change which leads to the transformation of one or more of the progeny of the initial irradiated...

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