Article
Mutagenic and chromosomal events in radiation transformation.
Biochimie - 1 Jan 2000
Little J B
Abstract excerpt
The transformation of a normal cell to a cancer cell is a complex multi-stage process. Data are presented from rodent cells which suggest that the initial radiation induced change does not represent a mutation in a specific structural gene or group of genes. Rather, DNA damage induced by radiation produces a heritable change which leads to the transformation of one or more of the progeny of the initial irradiated...
Topics
- Animals
- Cell Count
- Cell Division
- Cell Line
- Cell Transformation, Neoplastic
- Chromosome Aberrations
- Chromosomes
- Clone Cells
- DNA
- Diploidy
- Embryo, Mammalian
- Fibroblasts