Article
Expression of a mammalian DNA photolyase confers light-dependent repair activity and reduces mutations of UV-irradiated shuttle vectors in xeroderma pigmentosum cells.
Mutation research - 7 Dec 1999
Asahina H, Han Z, Kawanishi M, Kato T, Ayaki H, Todo T, Yagi T, Takebe H, Ikenaga M, Kimura S H
Abstract excerpt
Photoreactivation is one of the DNA repair mechanisms to remove UV lesions from cellular DNA with a function of the DNA photolyase and visible light. Two types of photolyase specific for cyclobutane pyrimidine dimers (CPD) and for pyrimidine (6-4) pyrimidones (6-4PD) are found in nature, but neither is present in cells from placental mammals. To investigate the effect of the CPD-specific photolyase on killing and...
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