Article
Divergent evolution of the activity and regulation of the glutamate decarboxylase systems in Listeria monocytogenes EGD-e and 10403S: roles in virulence and acid tolerance.
PloS one - 1 Jan 2014
Feehily Conor, Finnerty Aiden, Casey Pat G, Hill Colin, Gahan Cormac G M, O'Byrne Conor P, Karatzas Kimon-Andreas G
Abstract excerpt
The glutamate decarboxylase (GAD) system has been shown to be important for the survival of Listeria monocytogenes in low pH environments. The bacterium can use this faculty to maintain pH homeostasis under acidic conditions. The accepted model for the GAD system proposes that the antiport of glutamate into the bacterial cell in exchange for γ-aminobutyric acid (GABA) is coupled to an intracellular...
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