Article
Recent gene conversions between duplicated glutamate decarboxylase genes (gadA and gadB) in pathogenic Escherichia coli.
Molecular biology and evolution - 1 Oct 2007
Bergholz Teresa M, Tarr Cheryl L, Christensen Lisa M, Betting David J, Whittam Thomas S
Abstract excerpt
Escherichia coli have evolved adaptive systems to resist strongly acidic habitats in part through the production of 2 biochemically identical isoforms of glutamate decarboxylase (GAD), encoded by the gadA and gadB genes. These genes occur in E. coli and other members of the genospecies (e.g., Shigella spp.) and originated as part of a genomic fitness island acquired early in Escherichia evolution. The present...
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