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Similarities between bacterial GAD and human GAD65: Implications in gut mediated autoimmune type 1 diabetes

23 Feb 2022

Abstract excerpt

A variety of islet autoantibodies (AAbs) can predict and possibly dictate eventual type 1 diabetes (T1D) diagnosis. Upwards of 75% of those with T1D are positive for AAbs against glutamic acid decarboxylase (GAD65 or GAD), a producer of gamma-aminobutyric acid (GABA) in human pancreatic beta cells. Interestingly, bacterial populations within the human gut also express GAD and produce GABA. Evidence suggests that...

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PMID: 35196314
DOI: 10.1371/journal.pone.0261103

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