Enhanced HIV-1 immunotherapy by commonly arising antibodies that target virus escape variants.

doi:10.1084/jem.20141050

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Article

Enhanced HIV-1 immunotherapy by commonly arising antibodies that target virus escape variants.

The Journal of experimental medicine - 17 Nov 2014

Klein Florian, Nogueira Lilian, Nishimura Yoshiaki, Phad Ganesh, West Anthony P, Halper-Stromberg Ariel, Horwitz Joshua A, Gazumyan Anna, Liu Cassie, Eisenreich Thomas R, Lehmann Clara, Fätkenheuer Gerd, Williams Constance, Shingai Masashi, Martin Malcolm A, Bjorkman Pamela J, Seaman Michael S, Zolla-Pazner Susan, Karlsson Hedestam Gunilla B, Nussenzweig Michel C

Abstract excerpt

Antibody-mediated immunotherapy is effective in humanized mice when combinations of broadly neutralizing antibodies (bNAbs) are used that target nonoverlapping sites on the human immunodeficiency virus type 1 (HIV-1) envelope. In contrast, single bNAbs can control simian-human immunodeficiency virus (SHIV) infection in immune-competent macaques, suggesting that the host immune response might also contribute to...

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Identifiers

PMID: 25385756
DOI: 10.1084/jem.20141050
PMCID: PMC4235636

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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