Article
A single injection of crystallizable fragment domain-modified antibodies elicits durable protection from SHIV infection.
Nature medicine - 1 May 2018
Gautam Rajeev, Nishimura Yoshiaki, Gaughan Natalie, Gazumyan Anna, Schoofs Till, Buckler-White Alicia, Seaman Michael S, Swihart Bruce J, Follmann Dean A, Nussenzweig Michel C, Martin Malcolm A
Abstract excerpt
In the absence of an effective and safe vaccine against HIV-1, the administration of broadly neutralizing antibodies (bNAbs) represents a logical alternative approach to prevent virus transmission. Here, we introduced two mutations encoding amino acid substitutions (M428L and N434S, collectively referred to as 'LS') into the genes encoding the crystallizable fragment domains of the highly potent HIV-specific...
Topics
- Animals
- Antibodies, Monoclonal
- Antibodies, Neutralizing
- Antibodies, Viral
- Antibody Formation
- Crystallization
- Dose-Response Relationship, Immunologic
- HEK293 Cells
- Humans
- Injections