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Article

Trispecific broadly neutralizing HIV antibodies mediate potent SHIV protection in macaques

21 Sept 2017

Abstract excerpt

The development of an effective AIDS vaccine has been challenging because of viral genetic diversity and the difficulty of generating broadly neutralizing antibodies (bnAbs). We engineered trispecific antibodies (Abs) that allow a single molecule to interact with three independent HIV-1 envelope determinants: the CD4 binding site, the membrane-proximal external region (MPER), and the V1V2 glycan site. Trispecific...

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PMID: 28931639
DOI: 10.1126/science.aan8630

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