Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A single injection of anti-HIV-1 antibodies protects against repeated SHIV challenges.

Nature - 5 May 2016

Gautam Rajeev, Nishimura Yoshiaki, Pegu Amarendra, Nason Martha C, Klein Florian, Gazumyan Anna, Golijanin Jovana, Buckler-White Alicia, Sadjadpour Reza, Wang Keyun, Mankoff Zachary, Schmidt Stephen D, Lifson Jeffrey D, Mascola John R, Nussenzweig Michel C, Martin Malcolm A

Abstract excerpt

Despite the success of potent anti-retroviral drugs in controlling human immunodeficiency virus type 1 (HIV-1) infection, little progress has been made in generating an effective HIV-1 vaccine. Although passive transfer of anti-HIV-1 broadly neutralizing antibodies can protect mice or macaques against a single high-dose challenge with HIV or simian/human (SIV/HIV) chimaeric viruses (SHIVs) respectively, the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Immunoglobulin Fc Fragments
Share to AIDS Vaccines

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Antibodies, Neutralizing

Share to Half-Life

Share to HIV Antibodies

Share to Macaca mulatta

Share to Simian Acquired Immunodeficiency Syndrome

Share to Simian Immunodeficiency Virus

Source

Open in PubMed Open full text

Identifiers

PMID: 27120156
DOI: 10.1038/nature17677
PMCID: PMC5127204

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A single injection of anti-HIV-1 antibodies protects against repeated SHIV challenges.PMID 27120156Read ↗

A single injection of crystallizable fragment domain-modified antibodies elicits durable protection from SHIV infection.Semantic proximity Read ↗

Development of Antibodies with Broad Neutralization Specificities against HIV-1 after Long Term SHIV Infection in Macaques.Semantic proximity Read ↗

Long-acting capsid inhibitor protects macaques from repeat SHIV challengesSemantic proximity Read ↗

Enhanced Potency of a Broadly Neutralizing HIV-1 Antibody <i>In Vitro</i> Improves Protection against Lentiviral Infection <i>In Vivo</i>Semantic proximity Read ↗

Broadly neutralizing antibodies targeting the HIV-1 envelope V2 apex confer protection against a clade C SHIV challengeSemantic proximity Read ↗

Consistent Induction of Broadly Neutralizing HIV Antibodies by a Novel Two-Step Mechanism Informs Immunogen DesignSemantic proximity Read ↗

Antibodies: can they protect against HIV infection?Semantic proximity Read ↗

A novel HIV triple broadly neutralizing antibody (bNAb) combination-based passive immunization of infant rhesus macaques achieves durable protective plasma neutralization levels and mediates anti-viral effector functionsSemantic proximity Read ↗

Trispecific broadly neutralizing HIV antibodies mediate potent SHIV protection in macaquesSemantic proximity Read ↗

Most rhesus macaques infected with the CCR5-tropic SHIV AD8 generate cross-reactive antibodies that neutralize multiple HIV-1 strainsSemantic proximity Read ↗

Broadly Neutralizing Human Immunodeficiency Virus Type 1 Antibody Gene Transfer Protects Nonhuman Primates from Mucosal Simian-Human Immunodeficiency Virus InfectionSemantic proximity Read ↗

Transfer of neutralizing IgG to macaques 6 h but not 24 h after SHIV infection confers sterilizing protection: implications for HIV-1 vaccine development.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.