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Development of broadly neutralizing antibodies from autologous neutralizing antibody responses in HIV infection

25 Mar 2014

Abstract excerpt

PURPOSE OF REVIEW: Detailed genetic and structural characterization has revealed that broadly neutralizing antibodies (bnAbs) against HIV-1 have unusually high levels of somatic hypermutation, long CDRH3 domains, and the ability to target one of four sites of vulnerability on the HIV-1 envelope (Env) glycoproteins. A current priority is to understand how bnAbs are generated during natural infection, and translate...

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PMID: 24662931
DOI: 10.1097/coh.0000000000000057

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