Article
Common filaggrin gene mutations and risk of cervical cancer.
Acta oncologica (Stockholm, Sweden) - 1 Feb 2015
Bager Peter, Wohlfahrt Jan, Sørensen Erik, Ullum Henrik, Høgdall Claus Kim, Palle Connie, Husemoen Lise Lotte Nystrup, Linneberg Allan, Kjaer Susanne K, Melbye Mads, Thyssen Jacob P
Abstract excerpt
BACKGROUND: As carriers of filaggrin gene (FLG) mutations may have a compromised cervical mucosal barrier against human papillomavirus infection, our primary objective was to study their risk of cervical cancer. METHODS: We genotyped 586 cervical cancer patients for the two most common FLG mutations, R501X and 2282del4, using blood from the Copenhagen Hospital Biobank, Denmark. Controls (n = 8050) were genotyped...
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