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Article

No association between loss-of-function mutations in filaggrin and diabetes, cardiovascular disease, and all-cause mortality.

PloS one - 1 Jan 2013

Husemoen Lise Lotte N, Skaaby Tea, Jørgensen Torben, Thyssen Jacob P, Meldgaard Michael, Szecsi Pal B, Stender Steen, Johansen Jeanne Duus, Linneberg Allan

Abstract excerpt

BACKGROUND: Common loss-of-function mutations in the filaggrin gene (FLG) are a major predisposing risk factor for atopic disease due to reduced epidermal filaggrin protein levels. We previously observed an association between these mutations and type 2 diabetes and hypothesized that an inherited...

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Source

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Identifiers

PMID: 24367652
DOI: 10.1371/journal.pone.0084293
PMCID: PMC3867483

Genes

FLG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24367652-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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